Green Tea

Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites
Zhen Y, Cao S, Xue Y, Wu S Institute of Medical Biotechnology, CAMS, Beijing.

Chin Med Sci J 1991 Mar;6(1):1-5
The present study provides evidence that green tea extract (GTE), consisting of polyphenol components, is a highly active nucleoside transport inhibitor

GTE markedly inhibited radiolabeled thymidine and uridine transport in mouse leukemia L1210 cells, with IC50 values of 3.2 and 8.0 mumol/L, respectively. GTE blocked the rescue effect of exogenous nucleosides and enhanced the cytotoxicity of AraC and MTX to L1210 cells and human hepatoma BEL-7402 cells. GTE markedly potentiated the inhibitory effect of AraC on leukemia L1210 and P388 in mice. These results indicate that GTE is potentially useful when combined with antimetabolites in cancer chemotherapy.

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